THE EFFECT OF SE ON INCOPORATION OF ~3H-LEUCINE INTO MITOCHONDRIA IN THE LIVER OF RATS FED WITH SE-DEFICIENT DIET FROM KD ENDEMIC AREA
- VernacularTitle:硒对饲克山病病区粮大鼠肝线粒体~3H—亮氨酸参入的影响
- Author:
Wenle XIA
- Publication Type:Journal Article
- Keywords:
synthesis of protein;
selenium;
KD;
mitochondria ~3H-leucine
- From:Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
This paper studied the comparatively the changes of incorporation of ~3H-leucine into mitochondria of the liver from two groups of rats, one group fed with Se-deficiency diet from Keshan disease endemic area and the after with the same diet supplemented with sedium selenite. The results of our experiments indicated that the specific activity on incoporation of ~3H-leucine and hepatic GSH-px activity and contents of hepatic Se were significantly decreased and the TBA value was remarkably increased in the Se-deficiency diet group. The results suggested that the decrease of hepatic Se and GSH-px activities in the Se-deficiency rats might cause the accumulation of lipid hydroperoxides, which could lead to the destruction of the synthesie of protein in mitochondria. This may be one of important reasons which cause the decrease of respiratory enzyme activity in the cell.
