DIAGNOSIS AND TREATMENT OF MIDDLE-AGED AND SENILE DIABETES WITH RESPECT TO ? CELL FUNCTION AND INSULINRECEPTOR ACTIVITY
- VernacularTitle:自?细胞功能和胰岛素受体活性探讨中、老年糖尿病诊断和治疗
- Author:
Xixing ZHU
- Publication Type:Journal Article
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(04):-
- CountryChina
- Language:Chinese
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Abstract:
The insulinogenic index and RBC membrane insulin receptor analysis in 53 middle-aged and senile normal subjects and 66 cases of NIDDM showed that the amounts of insulin secreted in middle-aged and senile normal subjects were increased, whereas the insulin sensitivity of peripheral tissues and the numbers of RBC insulin receptors were decreased This might be one of the causative factors for glucose intolerance in middle-aged and senile normal subjects. In middle-aged and senile diabetics,the insulinogenic index,the insulin receptor number and the insulin binding capacity were lowered conspicuously than those in normal subjects with similar age.The diagnosis and treatment of senile diabetes were discussed. As to the management, stress may be placed on diet regulation, suitable physical exercise to prevent and control obesity and hypertension, etc. As long as hypoglycemic agent is indicated, sulfonylurea drugs capable of enhancing the glucose utilization in peripheral tissues should be the drug of choice and hypoglycemia be specially watched during the course.
