FASTING PLASMA GLUCAGON LEVEL AND GLUCAGON RESPONSE TO INSULIN-INDUCED HYPOGLYCEMIA IN NORMALS AND NIDDM PATIENTS
- VernacularTitle:正常人和Ⅱ型糖尿病患者血胰升糖素的基础值及对胰岛素所致低血糖的反应
- Author:
Zengchang WU
- Publication Type:Journal Article
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(04):-
- CountryChina
- Language:Chinese
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Abstract:
Pancreatic A cell function was studied in 119 cases of NIDDM with 37 normal subjects as controls. In NIDDM group, fasting plasma glucagon leveh averaged 192.9 ? 129.6 pg /ml, whereas in normals being 132.8?65.0 pg / ml. Plasma glucagon levels were markedly elevated in patients with NIDDM irrespective of insulin administration, suggesting decreased pancreatic A cell sensitivity to glucose.In 7 male normal subjects, following intravenous injection of insulin (0.1 U / kg) an average increment of 114 pg / ml of plasma glucagon level with a peak at 30-60 min was noted. In 3 of 6 male diabetic subjects a paradoxical reduced plasma glucagon response to insulin-induced hypoglycemia was demonstrated, suggesting primary abnormality of pancreatic A cell function in NIDDM patients, with a possible defect in glucose counter-regulation.
