NK Activity in PEC and Spleen Cells with the Stimulation of BCG
- VernacularTitle:BCG活化大鼠腹膜及脾NK细胞的活性
- Author:
Ning SU
- Publication Type:Journal Article
- From:
Chinese Journal of Immunology
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
The cytotoxic activity of WAB/NOT rats peritoneal exudate cells(PEC),spleencells were tested after the stimulation of large dose(Img)of BCG intraperitoneallyand intravenously. The data show the NK activity was increased markedly in PEC in a quantifiable5hr ~(51)C rrelease assay after 5 days stimulation by BCG.Nylon wool coloumn threa-tment had no significant effect on the cytotoxic activity in PEC but the carbonyl irontreatment did. The data suggest that rat NK cells in PEC are W3/25 negative when we used theantibody to label the cells and to sorter them on FACS. The data also show the suppressor cells were induced by BCG at the same time.Both NK cells and suppressor cells regulate immunological mechanism effected on tumor.
