Studies on T cell,T Cell Subpopulation and Natural Cell Activities of the Peripheral Blood Lymophocytes from Patients with Tumor
- VernacularTitle:肿瘤病人外周血T细胞及其亚群和NK细胞活性变化的研究
- Author:
Zhengren ZHOU
- Publication Type:Journal Article
- Keywords:
OKT monoclonal antibody;
NK activities;
~(51)Cr release cytotoxity.
- From:
Chinese Journal of Immunology
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
In this paper,we reported that T cell,T cell subpopulation and natural killer(NK)cell activities of peripheral blood lymophocytes from the Fatients with tumor weredetected with OKT monoclonal antibody and ~(51)Cr release cytotoxity test.The resultsshowed that percentage of OKT3~+,OKT4~+ cell in the peripheral blood of patients withtumor are low,OKT8~+ is high and the ratio of OKT4/OKT8 is low.The results haveproved that the ratio of OKT4/OKT8 and NK cell activities were significantly low inthe peripheral blood of patients with tumor.However,the activities have restored tonormal or near normal level in the patients after surgical operation for more that twoyears with no recurrence. Our data suggest that detecting of the ratio of OKT4/OKT8 and activities of NKcell might be valuable to the prognosis of patients with tumor.
