THE INHIBITING EFFECT OF ATROPINE ON GROWTH HORMONE RELEASE IN NORMAL SUBJECTS AND ACROMEGALIC PATIENTS
- VernacularTitle:阿托品对生长激素的抑制作用
- Author:
Jian ZHANG
- Publication Type:Journal Article
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(03):-
- CountryChina
- Language:Chinese
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Abstract:
Atropine, as an anticholinergic agent, can inhibit the synthesis of acetylcholine in the arcuate nucleus in hypothala-mus and then reduce the secretion of GH. The present study showed that GH secretion was increased during exercise and the elevated GH level could be inhibited by atropine in normal subjects, while in patients with active acromegaly the high basal GH levels could be inhibited neither by 100g of glucose loading nor by 0.6 mg atropine. The blood sugar concentrations remained unchanged during atropine test. It was suggested that atropine test could be used as a GH release inhibitory test in acromegalic patients with overt diabetes mellitus.
