AN INVESTIGATION OF SISTER CHROMATID EXCHANGE FREQUENCIES IN DIABETICS
- VernacularTitle:糖尿病病人姊妹染色单体互换频率及其影响因素的研究
- Author:
Zhenqi LIU
- Publication Type:Journal Article
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(03):-
- CountryChina
- Language:Chinese
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Abstract:
Sister chromatid exchange (SCE) frequencies were investigated in 35 diabetics and 24 controls. The spontaneous and MMC-induced SCE frequencies in diabetics were obviously higher than those in controls. There was a significant positive correlation between the spontaneous and MMC-induced SCE frequencies in either diabetics or controls. No correlation was found between the spontaneous SCE frequencies and HbA1 . High concentrations of glucose or regular insulin in the culture medium could not increase SCE frequencies of the controls. No significant difference was found between the untreated patients and patients treated with tolbutamide. The increased SCE frequency in diabetics may account for higher incidence of fetal stillbirth, abortion and malformations in diabetic pregnancies.
