The effects of different opiate peptides and ACTH on the phagocytosis of mouse macrophages
- VernacularTitle:几种阿片肽及ACTH对小鼠腹腔巨噬细胞吞噬功能的作用
- Author:
Xiaojing WANG
- Publication Type:Journal Article
- Keywords:
Macrophage;
Phagocytosis;
Neutral red;
Opiate peptides Naltrexone.
- From:
Chinese Journal of Immunology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Peritoneal macrophages were obtained from normal LACA mice and the phagocy-tosis of neutral red was measured after 24 hr.incubation with different opiate peptidesand ACTH.?-endorphin(10~-(10)-10~_6M)and dynorphin A(10~_(10)-1(10~_6M)were found tostimulate the phagocytosis and these increases in phagocytosis could be reversed byopiate receptor blocker,naltrexone(10~_5M).[D-Ala~2,D-Leu~5]-enkephalin(10~_(12)-10~_6M),however,had no effect on the phagocytosis.ACTH(10~_(10)-10~_6M)was fo-und to have suppressive effect on the phagocytosis.These results suggest that diffe-rent opiate peptides may cause different effects on phagocytosis of macrophages andthe increase in phagocytosis induced by ?-endorphin and dynorphin appears to be me-diated by opiate receptors on peritoneal macrophages.
