RESPONSE TO PULSATILE ADMINISTRATION OF LHRH IN NORMAL MEN AND PATIENTS WITH IDIOPATHIC HYPOGONADOTROPIC HYPOGONADISM
- VernacularTitle:正常男子及特发性低促性腺激素型性功能低减患者对自动脉冲注射LHRH的反应
- Author:
Guiyuan ZHANG
- Publication Type:Journal Article
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(02):-
- CountryChina
- Language:Chinese
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Abstract:
The gonadotropin and testosterone secretion of 20 normal men and 2 patients with IHH was investigated by pulsatile-subcutaneous administration of LHRH with a single dose of 5?g or 10?g per pulse in the former and 5?g per pulse at 90-min intervals in the latter. Blood samples for FSH, LH and T assays were drawn before and at 15, 30, 45, 60 and 90min after first pulse in normal men and one patient and on the 8th treatment day in the other patient. To observe the dynamic changes in hormone responses to pulsatile LHRH treatment in IHH, blood samples were also taken weekly aV interpulse period just before subsequent pulse. In normal men following a pulsatile injection of LHRH, the peak serum LH levels rose to 2.5 and 2.6 times as much as the basal at 30 min (5?g LHRH) and 45 min (10?g LHRH) respectively, peak FSH levels were elevated to 1.55- and 1.94-fold of the basal at 45 min, while only a tendency tp increase in T concentration was noted. No statistical significance was observed in LH, FSH and T levels between different, doses tested at any phase after LHRH administration in normal men. In IHH, LH, FSH and T levels showed no response after first pulsatile LHRH treatment yet they were increased significantly on the 8th day of treatment. The methodology of pulsatile administration of LHRH by portable pump and the relationship between the doses tested and their responses were discussed.
