ELEVATED GLOMERULAR FILTRATION RATE IN EARLY INSULIN-DEPENDENT DIABETES MELLITUS

VernacularTitle:早期胰岛素依赖型糖尿病患者的肾小球滤过率
Author: Juming LU
Publication Type:Journal Article
From: Chinese Journal of Endocrinology and Metabolism 1985;0(02):-
CountryChina
Language:Chinese
Abstract: GFR was measured by 99mTc-DTPA in 18 cases of IDDM and 12cases of NIDDM without detectable microvascular complications, and the results were compared with that of 17 controls. The GFR of IDDM was 150.7 ml/ min / 1.73m2 (M?SE), 25.1% higher than that of controls(120.5?4.1ml /min / 1.73m2). No relationship between the GRF in IDDM and the course of diabetes, blood sugar or glycosylated hemoglobin Ax was found. The GFR of NIDDM was not elevated. It suggests that elevated GFR might be one of the abnormal characteristics of renal functional changes in early IDDM. The mechanism of elevated GFR and its possible role in the development of diabetic nephropathy were discussed.