The probe of circulating immune complexes in thyroid diseases
- VernacularTitle:甲状腺疾病循环免疫复合物的探讨
- Author:
Qian SHEN
- Publication Type:Journal Article
- From:
Chinese Journal of Immunology
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Serum thyroglobulin(TG),anti-TG antibodies,circulating immune complexes(CIC)and circulating thyroglobulin-antithyroglobulin immune complexes(TG-IC)were studied using ??enzyme-linked immunosorbent assay(ELISA)in 147 sera of patients with thyroid diseases.The serum TG concentration,anti TG and IgG type CIC titer,and TG-IC were significantly increased in patients with Graves'diseases with clinical symptom phase and Hashimoto's thyroiditis,in patients with thyroid goiter,howerever,were sightly increased.The results found that CIC was detectable in 90% sera with TG-IC which contained high TG concentration and low or nagetive anti-TG antibodies.We belivedthat a part of CIC in thyroid autoimmune diseases were composed of TG-IC.TG-ICmight fix complement three(and thus bind to anti/C3 Serum)and play a pathogenic rolein thyroid autoimmune diseases.
