POLYMORPHISM OF DNA REGION ADJACENT TO THE 5' END OF INSULIN GENE OF HAN SUBJECTS IN CHINA
- VernacularTitle:中国汉族人胰岛素基因多态性的研究
- Author:
Jiali GU
- Publication Type:Journal Article
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(01):-
- CountryChina
- Language:Chinese
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Abstract:
The polymorphic characteristics of DNA region adjacent to the 5' end of the insulin gene in 83 Han subjects in China including 26 normal people and 57 diabetics were analysed by restriction endonuclease Bgl 1 gene mapping of chromosomal DNA. DNA fragments obtained by Bgl 1 digestion mainly contained 2.8 ? 0.3 kb (5%), 3.5?0.3kb (10%), 4.2 ? 0.3kb (46%) and 5?0.4kb (36%). In contrast with western white and black people, the above region is homozy-gous in 86% of the Han subjects analysed. This difference may be associated with the racial characteristics. No definite correlation between such polymorphism and the type of diabetes has been found.
