Ⅴ.Studies of human lymphocyte surface antigens Antigenic determinants recognized by monoclonal antibodies anti-CCT1 and anti-CCT3 and their function
- VernacularTitle:人淋巴细胞表面抗原的研究——Ⅴ.单克隆抗体anti-CCT1和anti-CCT3所识別的决定簇及其功能
- Author:
Yuxian CHEN
- Publication Type:Journal Article
- From:
Chinese Journal of Immunology
1985;0(01):-
- CountryChina
- Language:Chinese
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Abstract:
We have previously described two monoclonal antibodies,anti-CCT1 and antiCCT3,which recognize TP50 protein(associated with E-receptor)on human T cell surface.In this paper,the results of further studies on the determinants the two monolonal antibodies recognize and their functions are presented.anti-CCT3 blocked E rosette formation but anti-CCT1 did not.However,CCT1 and CCT3 determinantscould be.co-modulated by both monoclonal antibodies.When T cells were treated withboth antibodies simultaneously,the indirect immunofluorescence revealed by cytofluo-rograf was additive.Functionally,anti-CCT1 and anti-CCT3 were similar.Bothinhibited the proliferative response of peripheral blood lynphocyte to PHA and theexpression of IL-2 receptor.These results indicate that CCT1 and CCT3 are twodifferent epitopes on the TP50 molecules and are functionelly involved in the pro-liferation of T cells in response to mitogens.
