CLINICAL MANIFESTATIONS AND ENDOCRINOLOGICAL CHANGES AFTER PITUITARY APOPLEXY IN ACROMEGALY
- VernacularTitle:肢端肥大症垂体卒中临床及内分泌功能改变——垂体瘤内科性切除
- Author:
Yifan SHI
- Publication Type:Journal Article
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(04):-
- CountryChina
- Language:Chinese
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Abstract:
This article analysed the clinical manifestations and endocrinological changes after pituitary apoplexy in 8 fulminant acromegalic patients. Their secretory functions of pituitary hGH after pituitary apoplexy could be divided into two groups: 1) those with decrease of the reserve of pituitary hGH secretion; 2) those with decrease of pituitary hypersecretion of hGH, but still having pituitary reserve. In the former group, with almost full destruction of the pituitary tumors, basal serum hGH levels decreased to normal and showed no response to stimulation; and the functions of other pituitary-target axes were also influenced; as a result, obvious metabolic changes were noted and replacement therapy was needed. In the latter group, because of partial destruction of the pituitary tumors, the decreased serum hGH levels were not suppressed to normal, but showed response to stimulus; most of the functions of other pituitary-target axes were normal; thus these patients should be followed up carefully to see if they would relapse.Meanwhile, there were 10 cases of typical acromegaly with normal serum hGH levels, though they had not received any kind of therapy before. These patients might be considered as the silent type of pituitary apoplexy. In this series, the incidence is 2.4% for the fulminant type and 3.0% for the silent type.
