EFFECTS OF PGE_2 ON CARBOHYDRATE METABOLISM IN ALLOXAN-INDUCED DIABETIC AND NORMAL RATS
- VernacularTitle:前列腺素E_2对四氧嘧啶所致糖尿病大鼠及正常大鼠糖代谢作用的初步观察
- Author:
Junping LIU
- Publication Type:Journal Article
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(04):-
- CountryChina
- Language:Chinese
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Abstract:
The effects of PGE2 on glucose metabolism in alloxan-induced diabetic and normal rats were studied by subcutaneous injection of PGE2, with the serum levels of glucose, insulin and glucagon, and histopathological survey of pancreas as indices of assessment. The results revealed that the cytoprotective effect of PGE2 against the damage of pancreatic islets caused by alloxan was invisible, however, a slight reduction of serum glucose level, suppression of insulin secretion and stimulation of glucagon secretion were observed. The hypoglycemic effect of PGE2 in alloxan-induced diabetic rats seemed to be dosage dependent and probably related to temporary hyperglycemia and inhibiton of glucagon on glycogenolysis in liver. Thus, it might be suggested that PGE2 has no cytoprotective effect on pancreatic islets against alloxan damage, but is rather an important factor in regulating insulin and glucagon secretion as well as serum glucose level both in normal and alloxan-induced diabetic rats.
