ON SOME FACTORS RELATED TO THE PATHOGENESIS OF FAMILIAL HYPERTHYROIDISM WITH REFERENCE TO A SURVEY OF 30 FAMILIES
- VernacularTitle:有关家族性甲状腺机能亢进症发病的几个因素——附30例家系调查
- Author:
Xiumei ZAO
- Publication Type:Journal Article
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(02):-
- CountryChina
- Language:Chinese
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Abstract:
In order to elucidate the relationship between the pathogenesis of hyperthroidism and the genetic as well as environmental factors, clinical investigation and familial survey were performed on 30 cases each familial and non-familial hyper-thyroidism together with their 287 family members. More over, HLA of 52 members in 10 families with familial hyper-thyroidism were analysed. The results indicated that genetic factors were involevd in 27.3% of hyperthyroidism cases, and environmental factors in 83.3% cases that parental symptoms were not so severe as their siblings, and that the positive frequency of HLA-B60 antigen increased significantly (Pc
