ANALYSIS IN SITU ON ACTIVITY OF TUMORINFILTRATING LYMPHOCYTES IN HUMAN STOMACH AND COLON CANCER
- VernacularTitle:人胃肠癌组织中浸润淋巴细胞活性的原位分析
- Author:
Lisheng SI
- Publication Type:Journal Article
- Keywords:
stomach;
colon;
cancer;
lymphocyts
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1981;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
We have immunophenotyped the tumor-infiltrating mononuclear cells, especially the I_2 (HLA-DR) antigen and OKT_9 antigen expression on lymphocyte infiltrates to determine the activity of infiltrating T cells in 63 cases of advanced stomach and colon cancer. In addition, 18 specimens for biopsies from patients with chronic gastritis and colitis were used as controls. In most cancer specimens, the infiltrating T cells were defficient of I_2 antigen, only 10 out of 63 cases had about 10--30% I_2 positive infiltrating T cells, and nearly no OKT_9 positive infiltrating T lymphocytes. This finding is quite different from that in nomal mucosa and chronic inflammatory mucosa, with more I_2 positive lymphocytes in their infiltrates, indicating that the infiltrating T lymphocytes in tumor tissue inhibited by ome inhibitors present in their environment and contrabuting to the explanation why the tumor mmunity can not control the growth and spread of the tumor and lead to the elimination of the tumor.
