The Serum Immunosuppressive Activity in Patients With Systemic Lupus Erythematousus
- VernacularTitle:系统性红斑狼疮患者血清免疫抑制活性的探讨
- Author:
Jie HU
- Publication Type:Journal Article
- From:
Chinese Journal of Immunology
1985;0(03):-
- CountryChina
- Language:Chinese
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Abstract:
The serum suppressive activity on PHA-induced lymphocyte transformation of healthy individuals was evaluated in 76 serum samples from 55 patients with systemic lupus erythematousus(SLE).The serum suppressive activity seemed well correlated with the activity of SLE. The highest levels of suppressive rate (55.02+29.62％) and positive rate(88.33％)were found in patients with active disease. Once disease improved, both suppressive rate and positive rate were reduced (22.17?51.28％ and 51.85％ respectively), when the patients entered into stationary stage, the serum suppressive activity were not observed. The correlation between suppressive activity and lymphocyte transformation test, E-rosett inhibition factor, the levels of serum CIC, IgG, IgA, IgM. C3 and ANA titers were analysed. Stepwise discriminant analysis indicated that the serum suppressive activity was more closely related to disease activity than other immunological indexes. The nature of suppressive factor was discussed.
