Antitumor and Antimetastasis Activity of LAK cells
- VernacularTitle:LAK细胞的抗肿瘤抗转移作用
- Author:
Denian BA
- Publication Type:Journal Article
- Keywords:
LAK;
IL-2 Metastasis
- From:
Chinese Journal of Immunology
1985;0(01):-
- CountryChina
- Language:Chinese
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Abstract:
It has been shown that rat splenocytes incubated in IL-2 beoome lytic for WBT-2M fibrosarcoma cells of WKA rats and for SST-2 mammary carcinoma cells of SHR rats. We have performed the adoptive transfer of such LAK cells in WBT-2M and SST-2 met astasis models to test their in vivo efficacy. The LAK cells infused i. v. into WKA rats with WBT-2M fibrosarcoma and into SHR rats with SST-2 mammary carcinoma, led to marked decrease in the number of pulmonary metastatic nodules and to improve the survival of animals bearing SST-2. The combination of LAK cells and IL-2 provided a more effective antimetatic activity than LAK alone. T^he administration of LAK cells led to significantly decrease in the number of retained and survived tumor cells in lungs. The additional administration of LAK cells on day 3 and day 7 expressed a more marked inhibition of pulmonary metastatic formation of WBT-2M fibrosarcoma ia WKA rats. It was clear that LAK cells are not only able to kill curcular tumor cells, but also to destroy lung-retained tumor cells and the established WBT-2M pulmonary micrometastases. According to the results described above,it suggests that the use of LAK cells may provide a valuable method for the adoptive therapy of human neoplasmas as well.
