Effect of Ginseng Rhizome Saponin by cAMP and cGMP in the Formation of the E~*-Rosette of the Human Lymphocytes
- VernacularTitle:参芦总皂甙通过cAMP cGMP对人淋巴细胞E—玫瑰花结形成的影响
- Author:
Lanhua LOU
;
Xingde WO
- Publication Type:Journal Article
- Keywords:
Ginseng Rhizome Saponin;
cAMP, cGMP;
E-rosette formation(E-RFC);
Action rosette formation(Ea-RFC);
Total rosette formation(Et-RFC)
- From:
Chinese Journal of Immunology
1985;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
The concentration of the cyclic nucleotides and its relation with the E-RFC were determined by using ginseng rhizome saponin in human peripharal leukocytes.Result were compared with the ckange of the E-RFC by using cAMP.cGMP and theophylline. Experiments proved that girseng rhizome saponin mainly affected the lymphocytes and significantly increased the concentration of cAMP and cGMP,especially,the cAMP. Lymphocytes were incubated with ginseng rhizome saponin to form Et-RFC. It is different where lymphocytes were incubated in diffierent times. cAMP and theophylline reduced the Ea-RFC and Et-RFC, cGMP increased the Ea— RFC,but no effect to the Et-RFC. Ginseng rhizome or root saponin could promote the Ea-RFC,but inhibited the Et-RFC. It is consistent with the effect of both cAMP and cGMP. Experiments showed that ginseng rhizome saponin increased the concentration of cAMP and cGMP in human lyphocytes followed by that of E-RFC.It was suggested that the change of cyclic nucleotides in lymphocytes may be a mechanism of adjusting the immunity on cell level.
