IN VIVO AND IN VITRO STUDIES ON THE INHIBITION OF TESTICULAR FUNCTION BY GnRH-A IN MALE RATS
- VernacularTitle:GnRH-A对雄性大鼠睾丸内分泌功能的抑制作用
- Author:
Hongding XIANG
;
Zhisheng CHI
- Publication Type:Journal Article
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
The results showed that long-term and non-pulsatile administration of high doses of GnRH-A made in China produced a reversible inhibition of testicular endocrine function in male rats, resulting in decrease of testosterone level and increase of progesterone level both in sera and culture media. Besides, there was a marked decrease in the weight of their seminal vesicles and ventral prostates. It was found that GnRH-A we used had no effect on testis weight, the structure of seminiferous tubules and the production of estrogen by cultured Sertoli cells, and no serious side effect, either. It suggested that home made GnRH-A may be useful in the treatment of sex hormone-dependent diseases as reported in foreign literature.
