The protective effect of dopamine on the noiseinduced hearing loss of guinea pigs
- VernacularTitle:多巴胺对豚鼠噪声性听力损失的保护作用
- Author:
Lingling GUO
;
Lisheng YU
;
Xingqi LI
- Publication Type:Journal Article
- Keywords:
Animals,Laboratory;
Guinea Pigs;
Dopamine;
Cochlea;
Hearing Loss,Noise-Induced;
Action Potentials;
Cochlear Microphonic Potentials
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the protective effect and its frequency selection of dopamine on the inner cell in cochlea when exposed to white-noise;In order to offer an important step on understanding of negative protective modulation of dopamine in the cochlear auditory afferent nerve. METHODS Forty guinea pigs were randomly divided into 4 groups and whole intracochlear perfusions were performed. ① exposed to the 100dB white-noise; ② perfused with artificial perilymph solutions; ③exposed to the white-noise and perfused with artificial perilymph solutions; ④exposed to the white-noise and perfused with Artificial perilymph solutions containing 1mmol/L dopamine. Compound action potential(CAP)evoked by different frequencies tone pip, and cochlear mirophonics(CM)evoked by 4kHz tone burst were recorded from the round window of guinea pigs before and 2h after perfusion. RESULTS In the groups exposed to the white-noise, the CM amplitude and the linearity of input-output function both significantly decreased at 2h(P
