Antagonistic Effect of Compound Danshen Tablets on Nephrotoxicity Induced by Cyclosporine A
- VernacularTitle:复方丹参片对环孢素A肾毒性的拮抗作用研究
- Author:
Zheng ZHANG
;
Hongtao WANG
- Publication Type:Journal Article
- Keywords:
Salvia miltiorrhiza;
Cyclosporine A;
Nephrotoxicity;
Antagonistic
- From:
China Pharmacy
2007;0(32):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To investigate the antagonistic effect of Salvia miltiorrhiza on cyclosporine A (CsA)-induced chronic nephrotoxicity. METHODS: 54 patients underwent renal transplantation were divided into 3 groups according to dosage of salvia miltiorrhiza: CsA+high-dose of salvia miltiorrhiza group, CsA+loe-dose of salvia miltiorrhiza group (trial group) and CsA control group (control group). Plasma concentration of CsA, serum creatinine (Scr), blood urea nitrogen (Bun), 24 h urines and 24 h urinary protein were recorded. The parameters of morphology and hemodynamics were compared among 3 groups. The differences of index among 3 groups were analyzed statistically. RESULTS: The level of Scr, Bun and 24 h urinary protein in CsA+high-dose of salvia miltiorrhiza group were decreased significantly while 24 h urines was increased, compared with other 2 groups. There was significant difference among 3 groups (P0.05). The intrarenal blood flow and renal arterial resistance index were increased significantly in CsA+high-dose of salvia miltiorrhiza group. CONCLUSION: High-dose of salvia miltiorrhiza combined with CsA can reduce the CsA-induced nephrotoxicity perfently.
