Dosage Regimen Design of Aminophylline Using Pharmacokinetic Parameters
- VernacularTitle:用药动学参数制订氨茶碱的给药方案
- Author:
Puying CHEN
;
Li SUN
;
Xiaoman ZHANG
- Publication Type:Journal Article
- Keywords:
Aminophylline;
Dosage regimen;
Pharmacokinetic parameters;
Mean group value
- From:
China Pharmacy
2007;0(32):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To design the dosage regimen of aminophylline using reported pharmacokinetic parameters (mean group value). METHODS: The calculation of oral maintain dose, the infusion rate of intravenous drip maintain dose and the loading dose of intravenous drip were introduced. RESULTS: Different dose were required for different pathophysiological conditions insteading of aminophylline 200 mg three times a day (p.o.) for every patient. CONCLUSION: It is recommended that all hospitals which are unable to determine plasma concentration should design dosage regime of aminophylline using pharmacokinetic parameters.
