Effect of Buqi Huoxue Decoction on the Hemorheology and Tumor Necrosis Factor-? of Model Rats with Acute Cerebral Ischemia
- VernacularTitle:补气活血饮对急性脑缺血模型大鼠血液流变学及肿瘤坏死因子?的影响
- Author:
Shuke CUI
;
Chengzang LIU
;
Hui WANG
- Publication Type:Journal Article
- Keywords:
Buqi Huoxue Decoction(Herbal decoction for reinforcing qi and activating blood);
Acute cerebral ischemia;
Tumor necrosis factor-?(TNF-?);
Hemorheology;
Rats
- From:
Journal of Traditional Chinese Medicine
1992;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the interference actien of Buqi Huoxue Decoction(Herbal decoction for reinforcing qi and activating blood)on the model rats with acute cerebral ischemia.Methods Sixty SD rats were randomized into 6 groups,i.e.sham operation group,model group,nimodipine group,and Buqi Huoxue Decoction groups of high,middle,and low dosages,with 10 rats in each.Except the model and sham operation groups,the others were given Buqi Huoxue Decoction through intragastric gavage for 5 days.The acute cerebral ischemia models were made on the sixth day.One hour before modeling,the last medication was applied.At the time point 6h,12h,and 24h,the blood sample was taken from the aorta abdominalis for detecting the tumor necrosis factor-?(TNF-?).After 24h,the hemorheology test was performed.Results Compared with the model group,the whole blood viscosity including the high shear rate and low shear rate and erythrocyte aggregation index of the Nimodipine group and Buqi Huoxue Decoction groups of high and middle dosages were lowered(P
