Meta-analysis on Dronedarone in Treatment of Atrial Fibrillation or Atrial Flutter
- VernacularTitle:决奈达隆治疗房颤/房扑临床试验荟萃分析
- Author:
Wei SHI
;
Jiang SHAO
;
Xiaohua PANG
- Publication Type:Journal Article
- Keywords:
Dronedarone;
Atrial fibrillation;
Atrial flutter;
Meta-analysis
- From:
China Pharmacy
2007;0(30):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the efficacy and safety of dronedarone for atrial fibrillation or atrial flutter.METHODS:The publicly published literatures about the clinical trials on dronedarone for atrial fibrillation or atrial flutter were retrieved from PubMed.The quality analysis of included studies and extraction and cross-check of data were conducted by two reviewers independently using Meta-analysis.Response indexes were tested in tests for heterogeneity and summarized and analyzed using RevMan 5.0.The safety of dronedarone was evaluated.RESULTS:Five RCTs were included.As compared with placebo,dronedarone reduced the hospitalization rate due to cardiovascular events and all-cause mortality(RR=0.76,95%CI=0.72～0.79,P
