Analysis on Plasma Concentration Monitoring of Rifampicin and Isoniazid in Tuberculosis Patients
- VernacularTitle:我院结核病患者利福平和异烟肼血药浓度监测结果分析
- Author:
Jie ZHANG
;
Shuping HUANG
;
Di WU
- Publication Type:Journal Article
- Keywords:
Therapy drug monitoring;
Rifampicin;
Isoniazid
- From:
China Pharmacy
2007;0(30):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To promote plasma concentration monitoring of anti-tuberculosis agents in the clinic.METHODS:Results of plasma concentration monitoring of rifampicin and isoniazid in tuberculosis patients of our hospital from Aug.2005 to Dec.2008 were analyzed retrospectively.RESULTS:Plasma concentration samples were collected from 241 patients treated with rifampicin and 53 patients treated with isoniazid 2 hours after medication.Plasma concentrations of rifampicin in 10.4% of patients were below the normal level and 31.9% were higher than the normal level.Plasma concentrations of isoniazid in 71.7% of patients were below the normal level and 15.1% were higher than the normal level.CONCLUSION:Plasma concentration monitoring of anti-tuberculosis agents is a valuable tool to adjust the dosage of drugs,which is valuable for rational use of drugs in tuberculosis patients.
