Study on Equilibrium Solubility of Aesculin and Its Apparent Oil/Water Partition Coefficient
- VernacularTitle:秦皮甲素平衡溶解度及表观油/水分配系数的研究
- Author:
Yu JIANG
;
Qun HE
- Publication Type:Journal Article
- Keywords:
Aesculin;
Equilibrium solubility;
Apparent oil/water partition coefficient;
HPLC
- From:
China Pharmacy
2007;0(29):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To study the equilibrium solubility of aesculin and its apparent oil/water partition coefficient,and to provide basis for absorption mechanism study.METHODS: Equilibrium solubility of aesculin at the pH of 1.2～8.0 was determined by saturation method.The apparent oil/water partition coefficients of aesculin were determined by shaking flask method.RESULTS: The equilibrium solubility of aesculin at the pH of 1.2～6.8 was fluctuated slightly;it increased rapidly at the pH of 7.4;the maximum equilibrium solubility of aesculin was obtained at the pH of 8.0(10.58 g?L-1).The oil/water partition coefficient of aesculin changed slowly at the pH of 1.2～6.0;it decreased significantly at the pH of 6.0;the minimum oil/water partition coefficient was obtained at the pH of 8.0(0.03).CONCLUSIONS: The equilibrium solubility of aesculin and its apparent oil/water partition coefficient are associated with the pH of medium.The reason that aesculin has no effect on uric acid after oral administration is relevant to poor gastrointestinal tract absorption ability.
