Content Determination of Domiphen by Potassium Chromate Indicator Method
- VernacularTitle:铬酸钾指示剂法测定度米芬原料药含量
- Author:
Xianglan JIANG
;
Nannan YANG
;
Dongzhi YANG
;
Qisi LIN
- Publication Type:Journal Article
- Keywords:
Domiphen;
Content determination;
Potassium chromate indicator method;
Sodium tetraphenylborate method
- From:
China Pharmacy
2007;0(29):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To establish a method for the content determination of domiphen by potassium chromate indicator method.METHODS: The contents of domiphen were determined based on the theory that bromide ion in domiphon could react with AgNO3 to produce silver bromide precipitation.The method was compared with the sodium tetraphenylborate method issued in China Pharmacopeica(2005 edition).RESULTS: The RSD of contents was 0.18%,and the average recovery was 100.2% in the potassium chromate indicator method.There was no significant difference between the results of two determination methods by t-test.CONCLUSION: The potassium chromate indicator method is simple,fast and accurate,which can be used for the content determination of domiphen.
