Optimization of the Determination Method of Terbinafine Hydrochloride by Non-aqueous Potentiometric Titration
- VernacularTitle:非水电位滴定法测定盐酸特比萘芬原料药含量方法的改进
- Author:
Yihua ZHANG
;
Xuejing HAN
- Publication Type:Journal Article
- Keywords:
Non-aqueous potentiometric titration;
Terbinafine hydrochloride;
Raw material;
Acetic anhydride;
Content determination
- From:
China Pharmacy
2007;0(29):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To improve the determination method of terbinafine hydrochloride by non-aqueous potentiometric titration.METHODS: Potentiometric titration was adopted to determine the content of terbinafine hydrochloride using glacial acetic acid as solvent,acetic anhydride instead of mercury acetate.Results of improved determination method were compared with that of primary method.RESULTS: One abrupt change was obtained in the titration curve.The repeatability precision RSD was lower than 0.15%.Results of improved determination method were compared with that of primary method with maximum deviation of 0.1%.CONCLUSION: Improved method not only discards mercuric salt but also obtain obvious abrupt change of titration curve.It is simple and rapid for the determination of terbinafine hydrochloride.
