Development of Solid Supersaturatable Self-emulsifying Drug Delivery System of Vinpocetine
- VernacularTitle:长春西汀固体过饱和自乳化释药系统的研制
- Author:
Ying CHEN
;
Rong DU
;
Hong LIU
;
Bo DIAO
- Publication Type:Journal Article
- Keywords:
Vinpocetine;
Solid supersaturatable self-emulsifying drug delivery system;
Preparation;
In vitro dissolution;
Bioavailability;
Rats
- From:
China Pharmacy
2007;0(29):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To prepare solid supersaturatable self-emulsifying drug delivery system of vinpocetine(VIN-S-sSEDDS) and to study its characteristics in vitro and in vivo.METHODS: VIN-S-sSEDDS was prepared by spray drying using hydroxypropyl methyl cellulose(HPMC) as supersaturation promoter and dextran-40 as solid carrier.VIN-S-sSEDDS was compared with conventional self-emulsifying drug delivery system containing vinpocetine(VIN-SEDDS) in respects of particle size,in vitro dissolution and bioavailability in rats(ig.).RESULTS: The particle size of VIN-S-sSEDDS(58.78 nm) was smaller than that of VIN-SEDDS(65.12 nm).The accumulative dissolution of VIN-S-sSEDDS within 2 h(88.7%) was higher than that of VIN-SEDDS(58.2%).The bioavailability of VIN-S-sSEDDS in rats(2.30) was higher than that of VIN-SEDDS(1.63).CONCLUSION: Prepared VIN-S-sSEDDS could apparently improve the dissolution and bioavailability of VIN,and it is superior to conventional self-emulsifying preparation.
