Determination of Cytarabine and Uracil Arabinoside in Tissues of Rats by RP-HPLC
- VernacularTitle:RP-HPLC法测定小鼠各组织中阿糖胞苷及阿糖尿苷浓度
- Author:
Dongmei LV
;
Tao WANG
;
Shuling QIU
- Publication Type:Journal Article
- Keywords:
Cytarabine;
Uracil arabinoside;
RP-HPLC;
Mice
- From:
China Pharmacy
2007;0(29):-
- CountryChina
- Language:Chinese
-
Abstract:
0.998 8).The minimum detection limit were 0.1～0.4 mg?L-1.The average recovery rates were no less than 96%(RSD≤7.19%).There were significant difference among the concentration of Ara-C and Ara-U in plasma,cerebrospinal fluid and testicular tissue.Ara-C in plasma hadn't been determined in low-dose group and medium-dose group except for Ara-U.CONCLUSIONS: The method is simple,rapid,accurate and reproducible for plasma concentration monitoring and pharmacokinetic study of Ara-C and Ara-U.
