Analysis of Serum Concentration of Anti-epileptic in 2009
- VernacularTitle:我院2009年抗癫痫药物血药浓度监测结果分析
- Author:
Yujiao GUO
;
Weiqing WANG
;
Zhigao SHAO
;
Ping ZHAO
;
Hongwen ZHANG
- Publication Type:Journal Article
- Keywords:
Epileptic;
Serum concentration;
Monitoring;
Valproic acid;
Carbamazepine;
Phenytoin
- From:
China Pharmacy
2007;0(28):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To promote the clinical application and improve the curative effect of serum concentration.METHODS:In a retrospective review,the serum drug concentrations of 487 outpatients and inpatients of our hospital treated with 3 kinds of anti-epileptics included valproic acid,phenytoin and carbamazepine were analyzed.RESULTS:Among 487 samples,there were 248 cases(50.92%) whose serum concentration were in normal range,177 cases (36.34%) in low range and 51 cases(10.47%) in high range.Also,there were 11 cases(2.26%) whose serum concentration could not be monitored.The percentage of patients treated with valproic acid,carbamazepine and phenytoin whose serum concentrations in normal range were 48.18%,74.29% and 10.87%.CONCLUSION:The serum concentration monitoring of Anti-epileptic is the important measure which provide the basis for adopting individualized administration and ensures the clinical effect and safety in the medical care.
