Effects of Yinzhihuang Oral Solution on Immunological Liver Injury
- VernacularTitle:茵栀黄口服液在免疫性肝损伤中的作用研究
- Author:
Jun QIU
;
Rongfen HE
;
Liang GAO
- Publication Type:Journal Article
- Keywords:
Yinzhihuang oral solution;
Immunological liver injury;
Lipopolysaccharides;
Bacillus calmette-guerin vaccine;
oxidative stree
- From:
China Pharmacy
2007;0(27):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effects of Yinzhihuang oral solution on immunological liver injury (ILI). METHODS:Male mice were randomly divided into blank group (normal saline), model group (normal saline), bifendate group(150 mg?kg-1),high dosage group (Yinzhihuang oral solution 30 mL?kg-1), medium dosage group (Yinzhihuang oral solution 20 mL?kg-1) and low dosage group (Yinzhihuang oral solution 10 mL?kg-1). All rats were given medicine via i.g. gtt for 10 days. ILI model was induced by intravenous injection of bacillus calmette-guerin vaccine (BCG) and lipopolysaccharides (LPS). The content of IL-6 and TNF-? were detected by ELISA. The levels of ALT, AST, MDA and SOD were detected by spectrophotometer. RESULTS:Compared with model group, the level of ALT, AST, MDA, IL-6 and TNF-? were decreased significantly in high dosage, medium dose and low dosage groups (P
