Preparation of Osthole Microemulsion and Its Transdermal Absorption
- VernacularTitle:蛇床子素微乳的制备及其透皮能力的研究
- Author:
Qin WANG
;
Xinsheng PENG
- Publication Type:Journal Article
- Keywords:
Microemulsion;
Osthole;
Transdermal absorption
- From:
China Pharmacy
2007;0(27):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare osthole microemulsion and investigate its in vitro transdermal absorption ability.METHODS:The blank microemulsion formula was optimized based on the solubility of osthole in different oil phase,emulsifier,co-emulsifier and pseudo-tertiary phase diagrams.The viscosity,conductance and particle size of osthole microemulsion were investigated.The permeation rate of osthole was determined using drug diffusion apparatus.RESULTS:The viscosity,conductance and mean particle size of osthole microemulsion were 8.07 mpa?s,123 ?S?cm-1,58.0 nm,respectively.The steady permeation rate of osthole microemulsions reached(33.042?3.1)?g?cm-2?h-1(r=0.995 0)and it was 25.5 times over that of saturated osthole solution.CONCLUSION:The result indicates osthole microemulsion with high permeation rate may be used as new osthole preparation with transdermal delivery.
