Effect of Cinnamon Intervention on Oxidative Stress and Nerve Factor Expression in Rats with Chronic Cerebral Ischemia
- VernacularTitle:肉桂对慢性脑缺血大鼠氧化应激及神经因子表达的影响
- Author:
Wenfeng ZHANG
- Publication Type:Journal Article
- Keywords:
Cinnamon;
Chronic cerebral ischemia;
Cognitive ability;
Superoxide dismutase (SOD);
Malondialdehyde (MDA);
Nerve growth factor (NGF);
Brain-derived neurotrophic factor (BDNF)
- From:
Journal of Traditional Chinese Medicine
1993;0(07):-
- CountryChina
- Language:Chinese
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Abstract:
Objective To investigate the brain protection effect of cinnamon water extract on chronic cerebral ischemia rats. Methods We selected male Wistar rats to make chronic cerebral ischemia model by bilateral carotid artery ligation permanently,and the models were randomized into a model group,cinnamon high or low dose group,with 20 in each group. A control group with 20 rats was treated with sham operation. The cinnamon high and low dose groups were given cinnamon water extract 4.2g/kg and 2.1g/kg respectively by gavage in succession for 4 weeks. Y-maze test was used to test the cognitive ability of the rats. The superoxide dismutase (SOD) activity,malondialdehyde (MDA) content,and the expressions of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) were determined. Results Compared with the sham-operated group,the cognitive ability of the model group declined,the SOD activity of brain tissues decreased,and the MDA content increased. Cinnamon improved the SOD activity,reduced the MDA content,increased the NGF and BDNF expressions,and the effect of high-dose group was better than that of the low-dose group. Conclusion Cinnamon plays its role in cerebral protection through increasing the SOD activity and expression of NGF and BDNF and reducing content of MDA.
