Formulation Screening of Insulin Cream and Its Effects on Skin Injury in Model Rabbits
- VernacularTitle:胰岛素乳膏的处方筛选及对创伤模型家兔愈合的影响研究
- Author:
Ying ZHOU
;
Xiaoyan XUE
;
Zheng HOU
;
Hui BAI
;
Yingying CHEN
;
Xiaoxing LUO
- Publication Type:Journal Article
- Keywords:
Insulin;
Cream;
Matrix;
Formula screening;
Wound healing;
Rabbits
- From:
China Pharmacy
2007;0(25):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To screen formulation of Insulin cream and to investigate the effects of insulin cream on wound healing in rabbits.METHODS:The best formulation of insulin cream was selected from 8 kinds of formulations with appearance and stability as index.Rabbit trauma model were induced and divided into matrix group,blank group,Insulin cream groups(high-dose,medium-dose and low-dose).Wound healing rate and healing time were compared among those groups.RESULTS:The fifth formulation possessed good appearance and stability,which included albolene,cetanol,glycerin monostearate,glycerol,etc.Compared with matrix group,the wound healing rates were obviously increased at different time points in Insulin cream groups(P
