Study on the Influence Factors for the Preparation of Reverse Microemulsions and the Optimization of Its Formula
- VernacularTitle:反相微乳制备的影响因素考察及处方优化
- Author:
Lili CUI
;
Yingjie DENG
;
Yong ZHANG
;
Xiaodong DONG
;
Wenwen MO
- Publication Type:Journal Article
- Keywords:
Thymopentin;
Reverse microemulsions;
Pseudo-ternary phase diagram;
Oil phase;
Emulsifier;
Influence factors;
Optimization
- From:
China Pharmacy
2007;0(25):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the effect of oil phase,emulsifier and drugs on reverse microemulsion.METHODS:Pseudo-ternary phase diagram was adopted to study the effect of Span-80/Tween-80(emulsifier),thymopentin(model drug), long-chain glyceride,medium-chain glyceride,non-glyceride(oil phase).on the preparation of reverse microemulsions.Optimal formula of reverse microemulsions was selected.RESULTS:The largest water-in-oil(W/O)area was obtained in reverse microemulsion which was prepared using medium-chain glyceride as oil phase.Final formula was confirmed and contained distilled water/ Span-80/Tween-80/caprylic/capric triglyceride(2∶3∶6∶9).In addition,thymopentin was incorporated into the aqueous phase.CONCLUSIONS:The preparation of reverse microemulsions will be influenced by emulsifier,constitution of oil phase and drug.The influence factors for the actual preparation of reverse microemulsions should be optimized.
