Effect of regulatory T cell in SEB/OVA allergic rhinitis of animal model
- VernacularTitle:SEB/OVA变应性鼻炎模型中调节性T细胞的作用研究
- Author:
Jing MA
;
Tao LIU
- Publication Type:Journal Article
- Keywords:
Allergy and Immunology;
Rhinitis,Allergic,Perennial;
Disease Models,Animal;
T-Lymphocytes,Regulatory;
Staphylococcal enterotoxin B;
ovalbumin
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To establish mice model of allergic rhinitis(AR) and study the role of Staphylococcal enterotoxin B(SEB)and ovalbumin(OVA)in the model,and investigate the change of regulatory T cell(Treg)in the nasal mucosa of mice.METHODS Forty Balb/c mice were randomized into OVA group(A),SEB group(B),OVA+SEB group(C)and normal solution group(D).AR model was established.The symptom scores and count of Foxp3 positive cells in nasal mucosa were analyzed by factorial design.RESULTS The symptom scores in Group A,B,C,D were 0.90?0.99,0.70?0.82,6.80?1.03,0.60?0.70 respectively.Group C was successfully established as AR model.OVA and SEB had interaction(P
