Clinical Efficacy of Itraconazole in the Treatment of Invasive Fungal Infections in Patients of Intensive Care Unit
- VernacularTitle:伊曲康唑治疗重症监护患者侵袭性真菌感染的临床观察
- Author:
Jianming ZHANG
- Publication Type:Journal Article
- Keywords:
Itraconazole;
Intensive care unit;
Invasive fungal infection
- From:
China Pharmacy
2005;0(24):-
- CountryChina
- Language:Chinese
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Abstract:
OBJECTIVE:To observe clinical efficacy and safety of itraconazole in the treatment of invasive fungal infections(IFI) in patients of intensive care unit(ICU).METHODS:21 patients with IFI in ICU of Xinhua Hospital were analyzed retrospectively from Jan.to Sep.in 2009.Clinical efficacy and safety of itraconazole were analyzed.RESULTS:The total clinical cure rate reached 52.3%.Drug sensitivity test of 103 cases of bacterial strain culture showed those bacterial strains was sensitive to itraconazole.Total clearance rate of bacterial was 57.1%.Cure rate of confirmed diagnosis cases,clinical diagnosis cases and suspected cases were 33.3%,56.2% and 50.0%.The clearance rates of bacteria in above cases were 33.3%、62.5% and 50.0%.The incidence of ADR was 14.2%.CONCLUSION:Itraconazole is effective and safe in the treatment of IFI in patients of ICU.However,the patients with cardio dysfunction should be treated carefully with itraconazole.It is necessary to monitor vital sign and observe the change of symptom during medication.
