Systematic Review of Clinical Efficacy of Amlodipine in the Treatment of Variant Angina
- VernacularTitle:氨氯地平治疗变异型心绞痛的系统评价
- Author:
Peng XU
;
Guozhu ZHANG
- Publication Type:Journal Article
- Keywords:
Amlodipine;
Variant angina;
Vasospastic angina;
Systematic review
- From:
China Pharmacy
2005;0(24):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the clinical efficacy of amlodipine in treatment of vasospastic angina systematically.METHODS:Literatures were retrieved from MEDLINE,EMBASE,CNKI,CBM and Wanfang database,etc.Data of literatures were analyzed using RevMan 4.2 software.RESULTS:3 RCTs were included in meta-analysis and 1 RCT was involved in descriptive analysis.Compared with diltiazem,amlodipine was similar to benidipine in reducing the incidence of cardiovascular events;there was no statistical significance[OR=0.79,95%CI(0.57,1.10),P=0.16].Effective rate of amlodipine was significantly higher than isosorbide dinitrate,there were statistical significance[OR=7.33,95%CI(1.47,36.66),P=0.02].Compared with placebo,amlodipine could reduce occurrence times of angina significantly.CONCLUSION:Amlodipine is effective in treatment of vasospastic angina and can reduce the incidence of cardiovascular events in patients with vasospastic angina.
