Genetic Polymorphisms of CYP3A4 in Epilepsy Patients Treated with Carbamazepine
- VernacularTitle:服用卡马西平癫痫患者CYP3A4基因多态性的研究
- Author:
Jingxu NIE
;
Yan SONG
;
Jinju DUAN
- Publication Type:Journal Article
- Keywords:
CYP3A4;
Genetic polymorphism;
Carbamazepine;
PCR-RFLP
- From:
China Pharmacy
2005;0(24):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the genetic polymorphisms of cytochrome P4503A4(CYP3A4) in epilepsy patients treated with carbamazepine,and to provide reference for individual drug regimen.METHOD:Blood samples were collected from epilepsy patients treated with carbamazepines.Mutations in CYP3A4 gene were detected by polymerase chain reaction and restriction fragment length polymorphism(PCR-RFLP).RESULTS:After screening the 141 subjects,the individual mutation rates of the allele CYP3A4*4 and CYP3A4*6 were 0.71%.No allele CYP3A4*5 was found in 141 subjects.CONCLUSION:CYP3A4 genetic polymorphisms may change the activity of CYP3A4 gene.
