Protection Effects of Different Dosage of Reduced Glutathione on Liver Function in Acute Myeloid Leukemia Patients Undergoing Chemotherapy
- VernacularTitle:不同剂量还原型谷胱甘肽在急性髓系白血病化疗中对肝功能保护作用的临床观察
- Author:
Kaibo GAO
;
Yong TONG
;
Chun FENG
- Publication Type:Journal Article
- Keywords:
Reduced glutathione;
Acute myeloid leukemia;
Chemotherapy;
Liver function impairment
- From:
China Pharmacy
2005;0(24):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To discuss the protection effects of different dosage of reduced glutathione on liver function in acute myeloid leukemia(AML) patients undergoing chemotherapy.METHODS:In prospective study,72 AML patients were divided into group A and group B according to the dosage of reduced glutathione.Reduced glutathione were given to group A(1.2 g?d-1) and group B(2.4 g?d-1) 2 days before chemotherapy.Liver functions of patients were rechecked 1 week after chemotherapy.Another 2 weeks of treatment was given to patients with liver function disorder.RESULTS:1 week or 2 weeks after chemotherapy the incidence of liver function impairment in group B was decreased significantly,compared with group A(P
