Effect of Hydroxypropyl-?-Cyclodextrin on Solubility of Tacrolimus
- VernacularTitle:羟丙基-?-环糊精对他克莫司的增溶作用
- Author:
Qian ZHANG
- Publication Type:Journal Article
- Keywords:
Tacrolimus;
Hydroxypropyl-?-cyclodextrin;
Inclusion compound;
Solubility;
Solubilization effect
- From:
China Pharmacy
2007;0(25):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare tacrolimus-hydroxypropyl-?-cyclodextrin inclusion compound and to investigate the solubility of inclusion compound.METHODS:The inclusion compound was prepared by agitation method and identified by differential scanning calorimetry and X-ray diffraction analysis respectively.The solubility of inclusion compound was evaluated by phase-solubility method.RESULTS:The solubility of tacrolimus in water could be improved remarkably by hydroxypropyl-?-cyclodextrin and increased along with the increase of hydroxypropyl-?-cyclodextrin concentration and testing temperature.The solubility of tacrolimus was increased from 2.07 ?g?mL-1 to 167.74 ?g?mL-1 when the concentration of hydroxypropyl-?-cyclodextrin was 0.50 g?mL-1 at 25 ℃.Results of differential scanning calorimetry and X-ray diffraction analysis indicated inclusion compound was prepared successfully.CONCLUSION:Hydroxypropyl-?-cyclodextrin could increase the solubility of tacrolimus.
