Preparation and Quality Evaluation of Paclitaxel Microemulsion by Film Dispersion Method
- VernacularTitle:薄膜分散法制备紫杉醇微乳及其质量评价
- Author:
Lijuan ZHOU
- Publication Type:Journal Article
- Keywords:
Paclitaxel;
Film dispersion method;
Microemulsion;
Preparation;
Quality evaluation
- From:
China Pharmacy
2005;0(23):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To prepare paclitaxel microemulsion using film dispersion method and to evaluate the physicochemical property of it.METHEDS: The prescription was optimized with appearance,particle size and stability of paclitaxel microemulsion as indexes.The pH,appearance,morphology,particle size,stability of paclitaxel microemulsion were detected.The drug-loading rate and encapsulation efficiency were determined by HPLC.RESULTS: The paclitaxel microemulsion was translucent diluted-yellow solution with pH of 4.83 and stable property.Paclitaxel microemulsion droplet in electron microscopy consists of small spherical drops and Gauss distribution.The appearance,pH,drug-loading rate and particle size of microemulsion were stable after diluting with sodium chloride injection and glucose injection.The encapsulated efficiency and drug-loading rate of paclitaxel microemulsion were 97.03% and 3.032 g?L-1.CONCLUSION: The film dispersion method could be applied for the preparation of paclitaxel microemulsion which stable.It could not only solve the problem of its poor solubility but also relief remarkable hypersensitivity.
