Study of the protective effect of low molecular weight heparin on lung injury in severe acute pancreatitis in rats
- VernacularTitle:低分子量肝素对重症急性胰腺炎肺损伤保护作用的实验研究
- Author:
Fu QIU
;
Xinsheng LU
;
Yukun HUANG
- Publication Type:Journal Article
- Keywords:
Pancreatitis,Acute Necrotizing;
Low Molecular Weight Heparin;
Lung Injury;
Nuclear Factor Kappa B
- From:
Chinese Journal of General Surgery
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective efficiency of low molecular weight heparin (LMWH) on lung injury in severe acute pancreatitis (SAP).Methods SD rats were randomly divided into 3 groups:(1) Sham operation (S) group,(2) SAP group,(3) LMWH treatment (LT) group:LMWH was administrated 4 hours after SAP model was constructed.The levels of serum amylase,endothelin1(ET-1),tumor necrosis factor ? (TNF-?),lung wet/dry weight ratios,pulmonary morphology,the expressions of P65mRNA and P65 protein in pulmonary specimens were detected at 1d after the models were set up,and the 3 days survival rate in each group was also observed.Results (1) The levels of serum amylase,TNF-?,ET-1 in SAP group were significantly increased than those in S group and LT group (all P
