Progress of embryonic stem cells during directional differentiation regulated by epigenetic modification
- VernacularTitle:表观遗传修饰调控胚胎干细胞定向分化的研究进展
- Author:
Dingyuan LUO
;
Honghao LI
- Publication Type:Journal Article
- Keywords:
Epigenetic modification;
Embryonic stem cells;
cell differentiation
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Embryonic stem cells undergo extensive self-renewal and have the capacity to differentiate along multiple cell lineages.Research on totipotency and directional differentiation of embryonic stem cells in order to treat intractable disease,such as cancer,heart failure,atherosclerosis by tissue regeneration and cell transplantation are investigated.Epigenetic modification,including DNA methylation,chromatin restructure,and non-coding RNA-mediated regulatory events,regulate the differentiation of embryonic stem cells without detectable genetic changes.These mechanisms are often associated with starting-up and maintenance of epigenetic silence.The achievement and focuses on the molecular mechanism of embryonic stem cells during directional differentiation regulated by epigenetic modification are reviewed.
