Correlation of adiponectin gene SNP+45 T/G polymorphism with coronary heart disease
- VernacularTitle:脂联素基因SNP+45 T/G单核苷酸多态性与冠心病的相关性研究
- Author:
Li XU
;
Wenhua LING
- Publication Type:Journal Article
- Keywords:
Adiponectin;
Genes;
Polymorphism;
Coronary disease
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the relationship between adiponectin gene SNP+45 polymorphism and coronary heart disease(CHD) in south China Han population.METHODS: The nondiabetic CHD patients diagnosed by the coronary angiography were selected as CHD subjects(153 cases),and 73 healthy adults served as normal control subjects.The polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) was performed to identify the distribution pattern of adiponectin gene SNP+45 in all subjects.The levels of plasma adiponectin were measured by ELISA.RESULTS: The frequency of T/G + G/G genotype and G allele in CHD patients were significantly higher than those in control subjects(P
