Pathophysiological significance of ubiquition-proteasome system in myocardial infarction
- VernacularTitle:泛素-蛋白酶体系统在心肌梗死中的病理生理意义
- Author:
Yun ZHANG
;
Cuilian DAI
- Publication Type:Journal Article
- Keywords:
Ubiquitin proteasome system;
Heart;
Myocardial infarction
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Degradation of most proteins in eukaryotic cells is through the ubiquition-proteasome system(UPS).Recently,it demonstrated that UPS regulates cell apoptosis and cardiac hypertrophy.The differences of UPS regulation lie in E3 ligases,which specifically recognize targets and direct the ubiquitination process.Recent evidence suggests that atrogin-1/muscle atrophy F-box(Mafbx) and muscle RING finger 1(MuRF1) may be critical mediators of the heart and muscle atrophy and hypertrophy.This review summarizes the possible relationship between UPS and cardiac dysfunction after myocardial infarction in order to inhibit cardiac dysfunction after myocardial infarction.
