Efficacy Observation of Domestic Recombinant Human Interleukin-11(Ⅰ)in the Treatment of Thrombocytopenia Induced by Radiotherapy and Chemotherapy
- VernacularTitle:国产重组人白介素-11(Ⅰ)治疗肿瘤放、化疗引起血小板减少的疗效观察
- Author:
Hongyan LI
;
Huiping DING
- Publication Type:Journal Article
- Keywords:
IL-11(Ⅰ);
Malignant tumor;
Thrombocytopenia;
Clinical efficacy;
ADR
- From:
China Pharmacy
2005;0(22):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe clinical efficacy and ADR of domestic recombinant human interleukin-11(Ⅰ)(rhIL-11 (Ⅰ))in the treatment of thrombocytopenia in patients with malignant tumor. METHODS:In self-controlled trial,50 malignant tumor patients with thrombocytopenia induced by radiotherapy and chemotherapy were injected with 25 ?g?kg-1?d-1 rhIL-11(Ⅰ) subcutaneously. Drug withdrawal was conducted after consecutive 10 days injection or platelet count being higher than 300?109?L-1. RESULTS:The minimum mean value of platelet were(56.53?27.11)?109?L-1 after radiotherapy and chemotherapy and(126.73? 57.58)?109?L-1 after rhIL-11(Ⅰ)treatment(P
